PROTON PUMP INHIBITORS VS H2 ANTAGONISTS FOR STRESS ULCER PROPHYLAXIS: IS THERE A ROLE FOR NEPHROPROTECTION?
نویسندگان
چکیده
منابع مشابه
Cost-effectiveness analysis: stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 receptor antagonists.
OBJECTIVES Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) present varying pharmacological efficacy in preventing stress ulcer bleeding (SUB) in intensive care units. The literature also reports disparate rates of ventilator-assisted pneumonia (VAP) as side effects of these treatments. We compared the cost-effectiveness of these two prophylactic pharmacological options. METH...
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1. Bartram L et al. Survey of training in geriatric medicine in UK undergraduate medical schools. Age Ageing 2006; 35: 533–5. 2. Harden RM, Sowden S, Dunn WR. Some educational strategies in curriculum development. The SPICES model. Med Educ 1984; 18: 284–97. 3. Harden RM, Davis MH, Crosby JR. The new Dundee medical curriculum: a whole that is greater than the sum of the parts. Med Educ 1997; 31...
متن کاملProton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis.
BACKGROUND Critically ill patients may develop bleeding caused by stress ulceration. Acid suppression is commonly prescribed for patients at risk of stress ulcer bleeding. Whether proton pump inhibitors are more effective than histamine 2 receptor antagonists is unclear. OBJECTIVES To determine the efficacy and safety of proton pump inhibitors vs. histamine 2 receptor antagonists for the prev...
متن کاملIntravenous proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: determining statistical equivalence according to evidence-based methods.
BACKGROUND Although intravenous proton pump inhibitors (PPIs) are considered at least as effective as H2-receptors antagonists for stress ulcer prophylaxis (SUP) in critically ill patients, there is no data on whether there is also the proof of no difference among these agents. METHODS The clinical material was the same as that reported in previous meta-analyses and included all trials compar...
متن کاملHistamine-2 receptor antagonists versus proton pump inhibitors for stress ulcer prophylaxis in the ICU [version 1; referees: not peer reviewed]
An evaluation of a recent study by MacLaren R, Reynolds PM, Allen RR : et al Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the 2014, 564-574. intensive care unit. JAMA Intern Med 174: This article is included in the channel. Critical care Jeremy Kahn ( ) Corresponding author: [email protected] Kopterides P and Kahn ...
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ژورنال
عنوان ژورنال: Chest
سال: 2019
ISSN: 0012-3692
DOI: 10.1016/j.chest.2019.08.948